Effects of Gongronema latifolium Leaf Extract on Malondialdehyde Concentration of Wistar Rats Administered With a Toxic Dose of Ibuprofen

Aim: To determine effects of Gongronema latifolium leaf extract on Malondialdehyde (MDA) levels wistar rats induced by a toxic dose Ibuprofen. Material and Methods: Thirty were randomly divided into five groups with six in each group (n=6); Control (C) received normal feed only. T1 was administered 50 mg/kg BW+ Ibuprofen, T2: 100 T3: 150 T4: Jbruprofen only.This lasted for fourteen days. On the 15th day, blood samples collected level MDA then measured. Results: T1, T2, T3 showed significantly decreased when compared theT4 at p < 0.05. Conclusion: has an antioxidant effect prevention elevated levels.